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The concept for Gen:Lock originated in 2016 as a cautionary tale about cultural warfare.[3] It was announced with a brief teaser at RTX Austin 2017.[4] A trailer was shown at New York ComicCon 2017, where it was described as, "grounded science-fiction" in the tradition of mecha anime such as Gundam and Tom Clancy novels but with a look and feel reminiscent of RWBY.[5]
Gray Haddock cited several anime titles as inspirations, including Ghost in the Shell, Gundam, Aldnoah Zero, Kiznaiver, and the writing of Gen Urobuchi.[6]